ADVANCES IN ONCOLOGY: THE ROLE OF IMMUNOTHERAPY IN TREATING SOLID TUMORS

Authors

  • Haydarov Og'abek Ulug'bek ugli,Anvarov Navro'z Anvarovich,Mamatqulov Ismoil G'aybulla ugli,Hayitov Safarali Maxammadi ugli,Adxamov Asror Adxam ugli 4th-year student, Faculty of General Medicine Samarkand State Medical University, 5th- year students, Faculty of Pediatrics Samarkand State Medical University

Keywords:

Cancer immunotherapy, immune checkpoint inhibitors, solid tumors, PD-1/PD-L1, CAR-T cells, tumor microenvironment, precision oncology, cancer vaccine, biomarkers, clinical outcomes

Abstract

In the past decade, immunotherapy has revolutionized the field of oncology, offering new hope in the battle against solid tumors. Unlike conventional chemotherapy or radiotherapy, immunotherapy utilizes the patient’s immune system to identify and destroy malignant cells. It represents a paradigm shift in cancer treatment, particularly in cases where traditional therapies have failed or proven insufficient. This article provides an in-depth overview of the development, mechanisms, and current applications of immunotherapy in the treatment of solid tumors, including statistical evaluations of efficacy in various cancer types. The article also explores challenges, limitations, and the future direction of immunotherapy in the global fight against cancer.

Downloads

Download data is not yet available.

References

G‘iyosov A.T., To‘xtasinova M.B. (2023). Zamonaviy onkologiyada immunoterapiya yondashuvlari. Toshkent: O‘zMU nashriyoti.

Raxmatova Z.B. (2022). Qattiq o‘simtalarni davolashda immunologik terapiyaning o‘rni. Samarqand: SamDTU ilmiy jurnali.

International Sources

World Health Organization (2023). Cancer Fact Sheet. Geneva: WHO.

Ribas A., Wolchok J.D. (2018). Cancer immunotherapy using checkpoint blockade. Science, 359(6382), 1350–1355.

Hellmann M.D., et al. (2020). Nivolumab plus ipilimumab in advanced NSCLC. New England Journal of Medicine, 382(22), 2093–2104.

Hodi F.S., et al. (2018). Survival trends in advanced melanoma with checkpoint inhibitors. Journal of Clinical Oncology, 36(15), 1675–1684.

Sharma P., Allison J.P. (2020). The future of immune checkpoint therapy. Science, 348(6230), 56–61.

Hanna N.H., et al. (2021). Immunotherapy in solid tumors: From development to clinical implementation. The Lancet Oncology, 22(10), e450–e465.

Downloads

Published

2025-06-24

How to Cite

Haydarov Og'abek Ulug'bek ugli,Anvarov Navro'z Anvarovich,Mamatqulov Ismoil G'aybulla ugli,Hayitov Safarali Maxammadi ugli,Adxamov Asror Adxam ugli. (2025). ADVANCES IN ONCOLOGY: THE ROLE OF IMMUNOTHERAPY IN TREATING SOLID TUMORS. Journal of Applied Science and Social Science, 15(06), 716–719. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/1349

Most read articles by the same author(s)