EPIGENETIC MECHANISMS INVOLVED IN PRENATAL STRESS-INDUCED AUTISM RISK

Authors

  • Narbayeva Zamira Ravshanbekovna 4th year student, Faculty of Pedagogy, Defectology Alfraganus University

Keywords:

Maternal stress, pregnancy, autism spectrum disorder, epigenetics, DNA methylation, neurodevelopment, prenatal environment, histone modification

Abstract

Maternal stress during pregnancy has emerged as a critical environmental factor influencing fetal brain development and potentially contributing to the onset of autism spectrum disorder. This article explores the epigenetic mechanisms through which prenatal stress alters neurodevelopmental outcomes in offspring. By focusing on DNA methylation, histone modifications, and non-coding RNAs, the review highlights how stress-related hormonal changes in the intrauterine environment can affect gene expression patterns associated with neurodevelopment. Understanding these pathways offers new insight into preventive strategies and early interventions for autism spectrum disorder.

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References

Bale TL. Epigenetic and transgenerational reprogramming of brain development. Nat Rev Neurosci.

Monk C, Lugo-Candelas C, Trumpff C. Prenatal developmental origins of future psychopathology: Mechanisms and pathways. Annu Rev Clin Psychol.

Kundakovic M, Jaric I. The epigenetic link between prenatal adverse environments and neurodevelopmental disorders. Genes Brain Behav.

Meaney MJ. Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu Rev Neurosci.

Zijlmans MAC, Riksen-Walraven JM, de Weerth C. Associations between maternal prenatal cortisol concentrations and child outcomes: A systematic review. Neurosci Biobehav Rev.

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Published

2025-08-28

How to Cite

Narbayeva Zamira Ravshanbekovna. (2025). EPIGENETIC MECHANISMS INVOLVED IN PRENATAL STRESS-INDUCED AUTISM RISK. Journal of Applied Science and Social Science, 15(08), 521–524. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/1665

Issue

Vol. 15 No. 08 (2025): Volume 15 Issue 08

Section

Articles

License

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