THE REGENERATION OF NERVOUS TISSUES: THE DIFFERENCE BETWEEN VERTEBRATES AND HUMANS.
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xAbstract
The regeneration of nervous tissues is a fundamental topic in neuroscience and regenerative medicine, with significant implications for the treatment of injuries and neurodegenerative diseases. While many vertebrates demonstrate a remarkable capacity to regenerate components of their nervous system, humans have a relatively limited ability in this regard. This disparity has led to intense scientific interest in understanding the underlying biological mechanisms that govern nervous tissue regeneration across different species. In vertebrates such as fish and amphibians, neuronal regeneration is robust and efficient. For instance, zebrafish can regenerate entire sections of their spinal cord and optic nerve after injury. Similarly, salamanders are capable of regenerating complex neural structures, including limbs that contain nerve tissues. These regenerative processes are supported by the presence of active neural stem cells, permissive microenvironments, and reduced scarring and inflammation following injury.
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