PHARMACOLOGICAL RISKS OF LICORICE ROOT: HORMONE-MIMICKING COMPOUNDS AND NEPHROTOXIC EFFECTS
Keywords:
Glycyrrhiza glabra, glycyrrhizin, endocrine disruption, nephrotoxicity, pseudoaldosteronism, renal physiology, pharmacokinetics.Abstract
For centuries, Glycyrrhiza glabra, commonly known as licorice root, has been applied in both Eastern and Western medical traditions due to its wide spectrum of pharmacological benefits. Nevertheless, its active constituents, primarily glycyrrhizin and glycyrrhetinic acid, may elicit hormone-like effects that disturb the endocrine axis and renal physiology. This paper provides an in-depth exploration of the biochemical processes underlying these effects, the pharmacokinetic behavior of licorice metabolites, and the potential systemic consequences of chronic or excessive consumption
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