NEUROENDOCRINE MECHANISMS OF METABOLIC SYNDROME AND THEIR IMPLICATIONS FOR REHABILITATION PROGRAM DEVELOPMENT

Authors

  • Tyan Denis Lvovich Assistant of the Department of Rehabilitation, Traditional Medicine and Sports Medicine, Andijan State Medical Institute, Uzbekistan

Keywords:

metabolic syndrome, neuroendocrine mechanisms, HPA axis, sympathetic nervous system, rehabilitation, insulin resistance, cortisol, leptin resistance

Abstract

Metabolic syndrome (MetS) represents a cluster of interconnected metabolic abnormalities that significantly increase cardiovascular disease risk and type 2 diabetes mellitus. This review examines the neuroendocrine mechanisms underlying MetS pathophysiology, with particular emphasis on hypothalamic-pituitary-adrenal (HPA) axis dysfunction, sympathetic nervous system hyperactivity, and disrupted adipokine signaling. Understanding these mechanisms is essential for developing evidence-based rehabilitation interventions. We synthesize current knowledge on neuroendocrine dysregulation in MetS and discuss implications for designing targeted rehabilitation programs incorporating exercise, nutritional modification, and stress management strategies. The integration of neuroendocrine biomarkers into rehabilitation protocols may optimize therapeutic outcomes and enable personalized treatment approaches.

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Published

2025-10-18

How to Cite

Tyan Denis Lvovich. (2025). NEUROENDOCRINE MECHANISMS OF METABOLIC SYNDROME AND THEIR IMPLICATIONS FOR REHABILITATION PROGRAM DEVELOPMENT. Journal of Applied Science and Social Science, 15(10), 817–827. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/2122

Issue

Vol. 15 No. 10 (2025): Volume 15 Issue 10

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Articles

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