MIGRAINE IN MIDDLE-AGED PATIENTS: ANATOMICAL FEATURES OF SKULL AND BRAIN STRUCTURE IN ITS PATHOGENESIS, TREATMENT STRATEGIES AND PROLONGATION OF REMISSION

Authors

  • Jalilova Dilnavoz Abdug'ani qizi,Jo`raqulova Sangina Murodjon qizi Kimyo international university in Tashkent

Keywords:

Migraine, middle age, skull anatomy, brain structure, pathogenesis, treatment, remission, prevention.

Abstract

This study investigates the role of anatomical features of the skull and brain structures in the pathogenesis of migraine in middle-aged patients and evaluates effective treatment strategies along with methods to prolong remission periods. The research examines how variations in cranial and cerebral anatomy contribute to migraine susceptibility and severity, highlighting the importance of structural factors alongside genetic, hormonal, and environmental triggers. Both pharmacological and non-pharmacological interventions are analyzed, including acute and preventive medications, lifestyle modifications, stress management techniques, and digital health tools. Findings emphasize that individualized, multifactorial approaches integrating structural, clinical, and behavioral considerations are essential for reducing attack frequency, alleviating symptoms, and extending remission duration, thereby improving the overall quality of life for middle-aged migraine patients.

Downloads

Download data is not yet available.

References

Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017). Pathophysiology of migraine: A disorder of sensory processing. Physiological Reviews, 97(2), 553–622. https://doi.org/10.1152/physrev.00034.2015

Lipton, R. B., Bigal, M. E., Diamond, M., Freitag, F., Reed, M. L., & Stewart, W. F. (2007). Migraine prevalence, disease burden, and the need for preventive therapy. Neurology, 68(5), 343–349. https://doi.org/10.1212/01.wnl.0000252808.97649.21

Buse, D. C., Greisman, J. D., Baigi, K., & Lipton, R. B. (2019). Migraine progression: A systematic review. Headache: The Journal of Head and Face Pain, 59(3), 306–338. https://doi.org/10.1111/head.13448

Silberstein, S. D. (2015). Preventive treatment of migraine. Continuum (Minneap Minn), 21(4), 973–989. https://doi.org/10.1212/01.CON.0000466598.84795.e7

Ashina, S., Katsarava, Z., Do, T. P., Buse, D. C., Pozo-Rosich, P., & Goadsby, P. J. (2021). Migraine: Epidemiology, impact, and risk of progression. Headache, 61(8), 1232–1244. https://doi.org/10.1111/head.14179

Diener, H. C., Holle, D., Solbach, K., & Gaul, C. (2019). Migraine management and individualized prevention approaches. The Lancet Neurology, 18(10), 994–1005. https://doi.org/10.1016/S1474-4422(19)30219-3

Charles, A. (2017). Migraine: Pathophysiology, treatment, and preventive strategies. The New England Journal of Medicine, 377(19), 1889–1897. https://doi.org/10.1056/NEJMra1707079

Downloads

Published

2025-10-23 — Updated on 2025-10-23

Versions

How to Cite

Jalilova Dilnavoz Abdug'ani qizi,Jo`raqulova Sangina Murodjon qizi. (2025). MIGRAINE IN MIDDLE-AGED PATIENTS: ANATOMICAL FEATURES OF SKULL AND BRAIN STRUCTURE IN ITS PATHOGENESIS, TREATMENT STRATEGIES AND PROLONGATION OF REMISSION. Journal of Applied Science and Social Science, 15(10), 1234–1239. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/2205