BONE MARROW MICROARCHITECTURE ALTERATIONS IN ACUTE AND CHRONIC LEUKEMIAS

Authors

  • Yuldasheva Nodira Ergashevna Associate Professor, Department of Hospital Therapy and Endocrinology

Keywords:

bone marrow, microarchitecture, leukemia, hematopoiesis, blasts, histopathology, fibrosis

Abstract

The bone marrow is a highly specialized and dynamic organ that serves as the primary site of hematopoiesis and plays a central role in maintaining systemic homeostasis. In leukemias, whether acute or chronic, the normal microarchitectural integrity of the bone marrow is profoundly disrupted as malignant hematopoietic cells proliferate uncontrollably and infiltrate the marrow space. This pathological transformation affects every structural component — the hematopoietic cords, stromal framework, adipose tissue, and sinusoidal vasculature — leading to a complete reorganization of the bone marrow microenvironment.

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References

Orazi, A., Czader, M. B., & Thiele, J. (2019). Bone marrow pathology in leukemia. Modern Pathology, 32(1), 47–63.

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Arber, D. A., et al. (2016). The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood, 127(20), 2391–2405.

Bennett, J. M., & Brunning, R. D. (2018). Architectural remodeling of bone marrow in chronic leukemias. Seminars in Diagnostic Pathology, 35(3), 177–192.

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Published

2025-10-28

How to Cite

Yuldasheva Nodira Ergashevna. (2025). BONE MARROW MICROARCHITECTURE ALTERATIONS IN ACUTE AND CHRONIC LEUKEMIAS. Journal of Applied Science and Social Science, 15(10), 1422–1425. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/2247

Issue

Vol. 15 No. 10 (2025): Volume 15 Issue 10

Section

Articles

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