GENETIC BASIS OF AUTOIMMUNE HEPATITIS AND THE IMPACT OF HLA ALLELES ON DISEASE SUSCEPTIBILITY

Authors

  • Tairova Guzal Babakulovna,Abdurayimova Adiba Ahmadovna,Nurmamatova Iroda Abdivohidovna Tashkent State Medical University (Tashkent, Uzbekistan)

Keywords:

autoimmune hepatitis, HLA alleles, genetic predisposition, ethnic differences, liver.

Abstract

Autoimmune hepatitis (AIH) is a chronic autoimmune inflammatory liver disease characterized by an immune response directed against hepatocytes. The disease develops through the interaction of genetic and environmental factors. Studies indicate that genes of the human leukocyte antigen (HLA) system play a significant role in the development of AIH. Specific alleles of the HLA-DRB1, HLA-DQB1, and HLA-B genes increase susceptibility to the disease. This article analyzes the genetic basis of AIH, the association between HLA alleles and disease predisposition, as well as ethnic differences among populations.

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References

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Published

2025-10-28

How to Cite

Tairova Guzal Babakulovna,Abdurayimova Adiba Ahmadovna,Nurmamatova Iroda Abdivohidovna. (2025). GENETIC BASIS OF AUTOIMMUNE HEPATITIS AND THE IMPACT OF HLA ALLELES ON DISEASE SUSCEPTIBILITY. Journal of Applied Science and Social Science, 15(10), 1452–1455. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/2253

Issue

Vol. 15 No. 10 (2025): Volume 15 Issue 10

Section

Articles

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