ALCOHOLIC CIRRHOSIS:ETIOLOGY, DIAGNOSIS, TREATMENT

Authors

  • Jabborov Sherbek Otabek ugli Asia International University, Bukhara, Uzbekistan

Keywords:

Alcoholic cirrhosis; Alcohol-related liver disease (ARLD); Ethanol metabolism; Hepatic fibrosis; Liver biopsy.

Abstract

This article provides an overview of alcoholic cirrhosis, the most advanced form of alcohol-related liver disease (ARLD). It examines the etiology, emphasizing chronic alcohol consumption and its metabolic consequences leading to hepatic fibrosis. The paper explains the pathophysiology, including the biochemical mechanisms of ethanol metabolism and resultant oxidative stress. Clinical manifestations, diagnostic approaches, and treatment strategies-ranging from alcohol abstinence to liver transplantation-are discussed. The study also highlights the importance of prevention, nutritional rehabilitation, and patient education to reduce global morbidity and mortality associated with alcoholic cirrhosis.

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References

World Health Organization (WHO). (2023). Global status report on alcohol and health 2023. Geneva: WHO Press.

Schuppan, D., & Afdhal, N. H. (2008). Liver cirrhosis. The Lancet, 371(9615), 838–851. https://doi.org/10.1016/S0140-6736(08)60383-9

O'Shea, R. S., Dasarathy, S., & McCullough, A. J. (2010). Alcoholic liver disease. Hepatology, 51(1), 307–328. https://doi.org/10.1002/hep.23258

Rehm, J., Samokhvalov, A. V., & Shield, K. D. (2013). Global burden of alcoholic liver diseases. Journal of Hepatology, 59(1), 160–168. https://doi.org/10.1016/j.jhep.2013.03.007

Singal, A. K., Bataller, R., Ahn, J., Kamath, P. S., & Shah, V. H. (2018). ACG Clinical Guideline: Alcoholic Liver Disease. American Journal of Gastroenterology, 113(2), 175–194. https://doi.org/10.1038/ajg.2017.469

European Association for the Study of the Liver (EASL). (2018). EASL Clinical Practice Guidelines: Management of alcohol-related liver disease. Journal of Hepatology, 69(1), 154–181. https://doi.org/10.1016/j.jhep.2018.03.018

Tsochatzis, E. A., Bosch, J., & Burroughs, A. K. (2014). Liver cirrhosis. The Lancet, 383(9930), 1749–1761. https://doi.org/10.1016/S0140-6736(14)60121-5

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Published

2025-10-30

How to Cite

Jabborov Sherbek Otabek ugli. (2025). ALCOHOLIC CIRRHOSIS:ETIOLOGY, DIAGNOSIS, TREATMENT. Journal of Applied Science and Social Science, 15(10), 1505–1507. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/2265

Issue

Vol. 15 No. 10 (2025): Volume 15 Issue 10

Section

Articles

License

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