INVESTIGATION OF THE BIOLOGICAL ACTIVITY OF 1,3,4 – THIADIAZOLE DERIVATIVES
Keywords:
1,3,4-thiadiazole, synthesis, IR spectroscopy, biological activity, anti-inflammatory effect, hypoglycemic effect.Abstract
In this work, new 1,3,4-thiadiazole derivatives were synthesized. The structure of the obtained compounds was confirmed by IR spectroscopy. Their biological activity was studied, including acute toxicity, anti-inflammatory and hypoglycemic effects. The results showed that the synthesized compounds have low toxicity and exhibit pronounced anti-inflammatory and hypoglycemic activity, which makes them promise for further pharmacological studies.
Downloads
References
E. E. Oruc, S. Rollas, F. Kandemirli, N. Shvets, A. Dimoglo // J. Med. Chem., 2004. – 47. – 27. – P.6760-6767.
Y. Hu, C. Y. Li, X. M. Wang, Y. H. Yang, H. L. Zhu // Chem. Rev., 2014. – 114. – 10. – 5572– 5610.
K. Dickore, R. Wegler Formation of 1,3,4-thiadiazoles and 1,4,2-oxathiazoles from thioketenes Angew. Chem. Int. Ed. Engl., 5 (1966), p. 970
S. Treppendahl, P. Jackobsen The reaction of 4-substituted thiosemicarbazides with phenyl isocyanide, 1,3,4-thiadiazoles and 1,2,4-triazoles Acta Chem. Scand. Ser. B, 31 (1977), p. 264
Vasiliev A.V., Grinenko E. V., Shchukin A. O., Fedulina T. G. Infrared spectroscopy of organic and natural compounds. Educational settlement for chemical engineering students. and chemical and technical special higher educational institutions.St. Petersburg, 2007
Screening of antioxidant and anti-inflammatory activities among thiopyrano[2,3-d]thiazoles / A.V. Lozynskyi, D.V. Kaminskyy, Kh.B Romanchyshyn., N.G. Semenciv, V.V. Ogurtsov, I.O. Nektegayev, R.B. Lesyk // Вiopolymers and Cell. — 2015. — Т. 31, № 2. — С. 131-137. — Бібліогр.: 30 назв. — engl.
Mironov A..НN., БунатянBunatyan.N. D., et al. Guidelines for conducting preclinical drug trials. Part One, Moscow: Grif & K Publ., 2012, 944 p.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
All content published in the Journal of Applied Science and Social Science (JASSS) is protected by copyright. Authors retain the copyright to their work, and grant JASSS the right to publish the work under a Creative Commons Attribution License (CC BY). This license allows others to distribute, remix, adapt, and build upon the work, even commercially, as long as they credit the author(s) for the original creation.
