DIAGNOSTICS AND DIFFERENTIAL DIAGNOSIS OF DRUG-RESISTANT PULMONARY TUBERCULOSIS AT THE PRESENT STAGE

Authors

  • Zhurabaeva Muhabbat Khusanovna , Babamatova Hilola Umirsaidovna Tashkent State Medical University, PhD , Associate Professor of Department Tashkent State Medical University, Assistant Professor, Department Republican Specialized Scientific and Practical Medical Center for Phthisiology and Pulmonology, phthisiologist Tashkent, Uzbekistan

Keywords:

Tuberculosis, drug resistance, diagnostics

Abstract

Drug-resistant tuberculosis (DR-TB), particularly multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), poses a global public health threat and is a key factor hindering the success of tuberculosis control programs . Current DR-TB diagnostics are characterized by a transition from lengthy and insensitive culture methods to rapid molecular genetic technologies that allow resistance detection within hours or days. This review examines the main methods for DR-TB diagnostics, their advantages, limitations, and place in the diagnostic algorithm. Particular attention is paid to automated molecular platforms, next-generation sequencing (NGS) methods, and the prospects for their implementation in routine practice.

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References

Global Tuberculosis Report 2023. WHO.

WHO consolidated guidelines on tuberculosis. Module 3: Diagnosis – Rapid diagnostics for tuberculosis detection, 2021 update.

MacLean E, Kohli M, Weber SF, et al. Advances in Molecular Diagnosis of Tuberculosis. J Clin Microbiol . 2020.

Pai M., Schito M. Tuberculosis diagnostics in 2015: landscape, priorities, needs, and prospects. J Infect Dis. 2015.

Walker TM, Miott o P., Köser CU, et al. The 2021 WHO catalog of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis. Lancet Microbe . 2022.

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Published

2025-11-21

How to Cite

Zhurabaeva Muhabbat Khusanovna , Babamatova Hilola Umirsaidovna. (2025). DIAGNOSTICS AND DIFFERENTIAL DIAGNOSIS OF DRUG-RESISTANT PULMONARY TUBERCULOSIS AT THE PRESENT STAGE. Journal of Applied Science and Social Science, 15(11), 503–507. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/2425

Issue

Vol. 15 No. 11 (2025): Volume 15 Issue 11

Section

Articles

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