DISSEMINATED INTRAVASCULAR COAGULATION (DIC): PATHOGENESIS AND LABORATORY DIAGNOSIS
Keywords:
disseminated intravascular coagulation, coagulopathy, microthrombosis, fibrin degradation, laboratory diagnosis.Abstract
Disseminated intravascular coagulation (DIC) is a complex acquired syndrome characterized by widespread activation of the coagulation cascade, leading to microvascular thrombosis, consumption of clotting factors, and secondary hemorrhagic manifestations. It represents a final common pathway of various critical conditions, including sepsis, trauma, malignancy, obstetric complications, and severe inflammatory responses. This article reviews the pathogenesis of DIC with emphasis on the interplay between coagulation, platelets, endothelial dysfunction, and fibrinolysis. Additionally, it outlines key laboratory parameters essential for early recognition, diagnosis, and monitoring of the syndrome.
Downloads
References
Xamidov, A., Kholmirzayev, S., Rizayev, B., Umarov, I., Dadaxanov, F., & Muhtoraliyeva, M. (2022). The effectiveness of the use of monolithic reinforced concrete in the construction of residential buildings. Science and innovation, 1(A8), 991-996.
Kurtieva, S. (2021). Adaptation capabilities of functional systems of the body of adolescents with vegetative dystonia syndrome. International Journal of Health and Medical Sciences, 4(1), 129-135.
Nuralieva, D. M. (2020). CHARACTERISTICS OF MARRIAGE RELATIONS IN PROVIDING PSYCHOLOGICAL AID TO THE FAMILY AND IT INFLUENCE ON THE STRENGTH OF MARRIAGE. In Психологическое здоровье населения как важный фактор обеспечения процветания общества (pp. 411-414).
Kurtieva, S., Nazarova, J., & Mullajonov, H. (2021). Features of endocrine and immune status in adolescents with vegetative dystonia syndrome. International journal of health sciences, 5(2), 118-127.
Mukhitdinova, O., Alyavi, B. A., Ubaydullaeva, Z. Z., Uzokov, J. K., Mukhamedova, M. G., Rakhimova, D. A., ... & Orziev, D. Z. (2022). Changes of blood D-dimer level after COVID-19 in patients with coronary heart disease. European Heart Journal: Acute Cardiovascular Care, 11(Supplement_1), zuac041-136.
Паттахова, М., Закирходжаев, Ш., & Салихов, М. (2021). Оценка пищевого статуса пациентов с хроническими заболеваниями печени и их диетическая коррекция.
Kurtieva, S., Nazarova, J., & Mullajonov, H. (2021). Features of Physical and Generative Development of Modern Teenagers Living in Uzbekistan. NeuroQuantology, 19(7), 57-64.
Kurtieva, S. (2021). Clinical And Anamnestic Characteristics Of The Health State Of Adolescents With Vegetative Dysfunction Syndrome. The American Journal of Medical Sciences and Pharmaceutical Research, 3(06), 1-12.
Rakhmatova, M., Shakhanova, S., Nazarova, J., Azizova, F., Astanakulov, D., Akramov, G., & Mirametova, N. (2024). Brain tumor information retrieval system for brain tumor diagnosis. Health Leadership and Quality of Life, (3), 10.
Karimov, B., Bekmetova, F., Doniyorov, S., Bekmetova, S., Ilkhomova, L., & Arslonov, S. (2024). The correlation between indicators of time intervals of left ventricular activity and markers of myocardial damage in patients with non-ST-segment elevation acute coronary syndrome. Atherosclerosis, 395.
Nasirova, G. A., & Mukhamedova, M. G. (2023). Chronic heart failure and COVID-19. International Journal of Scientific Research Updates, 5(1), 138-42.
Azizova, F. L., Ermatov, N. J., & Kutliev, J. A. (2022). HYGIENIC RECOMMENDATIONS FOR ORGANIZING A HEALTHY DIET TO INCR EASE THE PHYSICAL ACTIVITY OF MILITARY ATHLETES. Art of Medicine. International Medical Scientific Journal, 2(1).
Куртиева, Ш., Иноятова, Ф. И., & Гафуров, Б. Г. (2021). ХОЗИРГИ ЗАМОН ЎСМИРЛАРИДА ФУНКЦИОНАЛ КАРДИОПАТИЯ СИНДРОМИНИ САБАБЛАРИ. Журнал теоретической и клинической медицины, (1), 39-42.
Azizova, F. (2019). Imaddedin Nasimi in the Medieval Sources and Literary Criticism. Teas Press.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
All content published in the Journal of Applied Science and Social Science (JASSS) is protected by copyright. Authors retain the copyright to their work, and grant JASSS the right to publish the work under a Creative Commons Attribution License (CC BY). This license allows others to distribute, remix, adapt, and build upon the work, even commercially, as long as they credit the author(s) for the original creation.
