PATHOPHYSIOLOGY OF SHOCK: MECHANISMS AND CLINICAL CONSEQUENCES

Authors

  • Madumarova M.M. Andijan State Medical Institute,Uzbekistan

Keywords:

shock, tissue hypoperfusion, microcirculation, cellular hypoxia, organ failure

Abstract

Shock is a life-threatening clinical syndrome characterized by inadequate tissue perfusion and oxygen delivery, leading to cellular dysfunction and organ failure. It represents a final common pathway of various pathological conditions, including trauma, infection, cardiac failure, and severe fluid loss. This article reviews the pathophysiological mechanisms of shock, focusing on circulatory failure, microcirculatory disturbances, cellular hypoxia, and metabolic alterations. The clinical consequences of shock, including multiple organ dysfunction and increased mortality, are also discussed. Understanding the underlying mechanisms of shock is essential for early recognition, appropriate treatment, and improved clinical outcomes.

Downloads

Download data is not yet available.

References

Солиев, Д. А., Абдуназаров, Т. А., Эшонхужаев, О. О., Эргашева, З. А., & Эшонхужаев, К. О. (2015). ФАРМАКОЭПИДЕМИОЛОГИЯ АНТИБАКТЕРИАЛЬНОЙ ТЕРАПИИ ПРИ ПАТОЛОГИИ БЕРЕМЕННЫХ. In АКТУАЛЬНЫЕ ВОПРОСЫ СОВРЕМЕННОЙ МЕДИЦИНЫ (pp. 314-316).

Джалалова, О., Алейник, В., Бабич, С., Ходжиматов, Г., Хамракулов, Ш., & Легкоев, A. (2019). Влияние взаимодействия казеина с жирами и жирными кислотами на протеолитическую активность поджелудочного и желудочного соков. Журнал вестник врача, 1(4), 46-53.

Мирзарахимова, М. А., & Кадиров, Ш. К. (2018). Ферментный гомеостаз и секреция ферментов поджелудочной железы у крыс при сочетанном влиянии гипокинезии, высокой температуры и инсоляции. Молодой ученый, (5), 52-55.

Ziablitskiĭ, V. M., Romanovskaia, V. N., Umurzakova, R. Z., & Starosel'skaia, A. N. (1996). Modification to the functional status of the hemostatic system with the use of berberine sulfate. Eksperimental'naia i Klinicheskaia Farmakologiia, 59(1), 37-39.

Джалалова, О. К., Алейник, В. А., Бабич, С. М., Ходжиматов, Г. М., & Легкоев, А. Ю. (2019). Влияние белково-жировых эмульсий на изменение протеолитической активности поджелудочного сока. Re-health journal, (2), 109-117.

Downloads

Published

2025-12-12

How to Cite

Madumarova M.M. (2025). PATHOPHYSIOLOGY OF SHOCK: MECHANISMS AND CLINICAL CONSEQUENCES. Journal of Applied Science and Social Science, 15(12), 459–462. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/2617

Issue

Vol. 15 No. 12 (2025): Volume 15 Issue 12

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All content published in the Journal of Applied Science and Social Science (JASSS) is protected by copyright. Authors retain the copyright to their work, and grant JASSS the right to publish the work under a Creative Commons Attribution License (CC BY). This license allows others to distribute, remix, adapt, and build upon the work, even commercially, as long as they credit the author(s) for the original creation.