CLINICAL SIGNIFICANCE OF ANTI-CITRULLINATED CYCLIC PEPTIDE (ASSP) IN EARLY DIAGNOSIS OF RHEUMATOID ARTHRITIS AND ITS IMPACT ON REPRODUCTIVE HEALTH: A PRELIMINARY OBSERVATIONAL STUDY

Authors

  • Soliyev Muhammadqodir Abdugffor ugli Andijan State Medical Institute, Department of Family Medicine
  • Saliyev Dilmurod Qodirovich Andijan State Medical Institute, Department of Family Medicine
  • Soliyev Alisher Qodirovich Andijan State Medical Institute, Department of Family Medicine
  • Inomov Kamoliddin Mamasoli ugli University of Business and Science, Department of Medicine
  • Karimjonov Jaloliddin Abdusattor ugli University of Business and Science Department of General Professional Subjects

Keywords:

Rheumatoid arthritis, ASSP, Rheumatoid factor, Reproductive health, Autoimmunity.

Abstract

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that predominantly affects women of reproductive age. In addition to joint inflammation, systemic autoimmunity can impair hormonal regulation and reproductive function. Early diagnosis plays a crucial role in preventing irreversible joint damage and reproductive complications.

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References

Smolen JS, et al. (2020). Rheumatoid arthritis. Nat Rev Dis Primers. 6(1):1–19.

Qingmei Cao et al. Clinical significance of combined anti-CCP antibody and RF assays in rheumatoid arthritis diagnosis. Arch Rheumatol. 2015.

Mankia K, et al. (2021). “Preclinical RA and autoantibody-positive arthralgia: advances in pathogenesis and prevention.” Nat Rev Rheumatol. 17: 593–604.

Kobayashi M et al. Anti-CCP antibodies and fertility outcomes in women with rheumatoid arthritis: a cohort analysis. Clin Exp Rheumatol. 2022.

Ahmed H, Patel V, Singh R. Reproductive outcomes in autoimmune diseases: recent evidence and therapeutic strategies. BMC Women’s Health. 2023.

Tursunova MA, Sattarov OKh. — “Assessment of the quality of life of patients with rheumatoid arthritis”. 2022.

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Published

2025-12-14

How to Cite

Soliyev Muhammadqodir Abdugffor ugli, Saliyev Dilmurod Qodirovich, Soliyev Alisher Qodirovich, Inomov Kamoliddin Mamasoli ugli, & Karimjonov Jaloliddin Abdusattor ugli. (2025). CLINICAL SIGNIFICANCE OF ANTI-CITRULLINATED CYCLIC PEPTIDE (ASSP) IN EARLY DIAGNOSIS OF RHEUMATOID ARTHRITIS AND ITS IMPACT ON REPRODUCTIVE HEALTH: A PRELIMINARY OBSERVATIONAL STUDY. Journal of Applied Science and Social Science, 15(12), 535–537. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/2639

Issue

Vol. 15 No. 12 (2025): Volume 15 Issue 12

Section

Articles

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