DISRUPTION OF THE SKIN MICROBIOME AND DERMATOLOGICAL DISEASES.
Keywords:
Skin microbiome; Dysbiosis; Dermatological diseases; Atopic dermatitis; Acne; Psoriasis; Microbiome-targeted therapy.Abstract
The skin microbiome plays a crucial role in maintaining skin health by protecting against pathogens, modulating the immune response, and supporting barrier function. Disruption of this delicate microbial ecosystem, also known as dysbiosis, has been increasingly linked to various dermatological diseases. Conditions such as atopic dermatitis, acne, psoriasis, and rosacea have been associated with changes in microbial diversity, abundance, and community structure. Factors contributing to microbiome disruption include antibiotic use, environmental changes, lifestyle factors, and host immune dysfunction. Understanding the interactions between the skin microbiome and host physiology provides valuable insights into the pathogenesis of skin disorders and offers potential avenues for novel therapeutic strategies, including microbiome-targeted interventions.
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