OPPORTUNITIES FOR EARLY PROGNOSIS OF PRE-ECLAMPSIA IN THE FIRST TRIMESTER

Authors

  • Abdurashidova Khaitkhon Bektemir kizi Department of 1-Obstetrics and Gynecology, Andijan State Medical Institute, Andijan, Uzbekistan

Keywords:

Pre-eclampsia, first trimester screening, PlGF, uterine artery Doppler, mean arterial pressure, aspirin prophylaxis.

Abstract

Background: Pre-eclampsia (PE) remains a leading cause of maternal and perinatal morbidity and mortality. Traditional screening based solely on maternal history has poor sensitivity. This study aims to evaluate the efficacy of a multi-parametric screening model in the first trimester (11-13 weeks) for the early prediction of pre-eclampsia. Methods: A prospective cohort study involving 500 pregnant women was conducted. All participants underwent screening at 11-13+6 weeks, which included: assessment of maternal risk factors, measurement of Mean Arterial Pressure (MAP), Doppler ultrasonography of the uterine arteries (UtA-PI), and serum analysis for PAPP-A and PlGF. The risk was calculated using the Fetal Medicine Foundation (FMF) algorithm. Results: The combined screening model (Maternal factors + MAP + UtA-PI + PlGF) achieved a detection rate of 92% for early-onset PE and 76% for late-onset PE, with a false-positive rate of 10%. In contrast, screening based on maternal history alone detected only 35% of cases. Women identified as high-risk were started on low-dose aspirin (150 mg) prophylaxis. Conclusion: Combined first-trimester screening provides a highly accurate method for identifying women at high risk of pre-eclampsia. Early identification allows for timely prophylactic intervention with aspirin, significantly improving maternal and fetal outcomes.

Downloads

Download data is not yet available.

References

Rolnik, D. L., et al. (2017). Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia. New England Journal of Medicine, 377(7), 613-622.

Poon, L. C., et al. (2019). The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention. International Journal of Gynecology & Obstetrics, 145(S1), 1-33.

Akolekar, R., et al. (2013). Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11-13 weeks gestation. Fetal Diagnosis and Therapy, 33(1), 8-15.

Chaemsaithong, P., et al. (2014). First trimester screening for preeclampsia. Current Opinion in Obstetrics and Gynecology, 26(6), 469-478.

O’Gorman, N., et al. (2016). Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11-13 weeks gestation. American Journal of Obstetrics and Gynecology, 214(1), 103.e1-103.e12.

Downloads

Published

2025-11-08

How to Cite

Abdurashidova Khaitkhon Bektemir kizi. (2025). OPPORTUNITIES FOR EARLY PROGNOSIS OF PRE-ECLAMPSIA IN THE FIRST TRIMESTER. Journal of Applied Science and Social Science, 15(11), 907–911. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/2899

Issue

Vol. 15 No. 11 (2025): Volume 15 Issue 11

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All content published in the Journal of Applied Science and Social Science (JASSS) is protected by copyright. Authors retain the copyright to their work, and grant JASSS the right to publish the work under a Creative Commons Attribution License (CC BY). This license allows others to distribute, remix, adapt, and build upon the work, even commercially, as long as they credit the author(s) for the original creation.