PREGNANCY OUTCOMES IN WOMEN WITH A HISTORY OF PREECLAMPSIA: A RETROSPECTIVE STUDY IN ANDIJAN REGION

Abstract

Background: Women with a history of preeclampsia (PE) are at significantly elevated risk for recurrence in subsequent pregnancies, as well as for long-term cardiovascular complications. This study aims to analyze the recurrence rate of preeclampsia and perinatal outcomes in women who experienced hypertensive disorders in their previous pregnancy within the population of the Andijan region. Methods: A retrospective cohort study was conducted at the Andijan Regional Perinatal Center (2021–2024). The study included 250 multiparous women: Group A (n=120) included women with a history of PE in their first pregnancy, and Group B (n=130) included women with a normotensive first pregnancy. Maternal characteristics, inter-pregnancy intervals, and current pregnancy outcomes were analyzed. Results: The recurrence rate of preeclampsia in Group A was 24.2% (29/120), compared to a new onset rate of 3.1% in Group B (p < 0.001). Women who had early-onset PE (<34 weeks) in their first pregnancy had a significantly higher recurrence risk (45.0%) compared to those with late-onset PE (18.0%). Adverse perinatal outcomes, including preterm birth and low birth weight, were two times more frequent in the recurrence group. Conclusion: A history of preeclampsia is the single strongest predictor of adverse outcomes in subsequent pregnancies. In the Andijan region, the recurrence rate remains high, necessitating targeted preconception counseling and mandatory aspirin prophylaxis for this high-risk demographic.