HISTOGENESIS OF HEMATOPOIETIC AND IMMUNE ORGANS DURING PRENATAL AND EARLY POSTNATAL DEVELOPMENT

Authors

  • Bekjanova Gulnara Marxabaevna,Turanova Shoxida Yunusalievna candidate of medical sciences senior teacher of the department of Medical biological sciences, EMU University,teacher of the department of Medical biological sciences, EMU University

Keywords:

histogenesis, hematopoiesis, hematopoietic stem cell, fetal liver niche, bone marrow microenvironment, thymus development.

Abstract

This article reviews how hematopoietic and immune organs are built during prenatal life and how they rapidly adjust after birth. Developmental blood formation does not stay in one place. It shifts through a sequence of anatomical niches that provide distinct cellular signals and structural support. Early embryonic hematopoiesis begins outside the embryo, then definitive hematopoietic stem cells arise within embryonic vessels and seed fetal organs where expansion and lineage specification occur.

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References

Orkin S H, Zon L I. Hematopoiesis: an evolving paradigm for stem cell biology // Cell. 2008. Vol. 132. No. 4. P. 631-644. DOI: 10.1016/j.cell.2008.01.025.

Haddad R, Guimiot F, Six E, Jourquin F, Setterblad N, Kahn E, Yagello M, Schiffer C, Andre-Schmutz I, Cavazzana-Calvo M, Gluckman J C, Delezoide A L, Pflumio F, Canque B. Dynamics of thymus-colonizing cells during human development // Immunity. 2006. Vol. 24. No. 2. P. 217-230. DOI: 10.1016/j.immuni.2006.01.008.

Lewis K, Yoshimoto M, Takebe T. Fetal liver hematopoiesis: from development to delivery // Stem Cell Research and Therapy. 2021. Vol. 12. Article 139. DOI: 10.1186/s13287-021-02189-w.

Moore K L, Persaud T V N, Torchia M G. The Developing Human: Clinically Oriented Embryology. 11th ed. Saunders, 2019.

Abbas A K, Lichtman A H, Pillai S, Henrickson S. Cellular and Molecular Immunology. 11th ed. Elsevier, 2025.

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Published

2026-02-06

How to Cite

Bekjanova Gulnara Marxabaevna,Turanova Shoxida Yunusalievna. (2026). HISTOGENESIS OF HEMATOPOIETIC AND IMMUNE ORGANS DURING PRENATAL AND EARLY POSTNATAL DEVELOPMENT. Journal of Applied Science and Social Science, 16(02), 114–116. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/3166

Issue

Vol. 16 No. 02 (2026): Volume 16 Issue 02

Section

Articles

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