CELLULAR-LEVEL EFFECTS OF MYOCARDIAL HYPOXIA

Authors

  • Alimjonov Azizulloh Kokand University, Andijan Branch Faculty of Medicine, Pediatrics Program

Keywords:

myocardial hypoxia, cardiomyocytes, cellular metabolism, ATP deficiency, mitochondria, oxidative stress, free radicals, apoptosis, necrosis, pediatrics.

Abstract

 Myocardial hypoxia is a significant pathophysiological condition that develops as a result of insufficient oxygen supply to cardiac muscle cells and represents a particularly relevant problem in pediatric practice. Due to the incomplete development of the cardiovascular system in children, sensitivity to hypoxic conditions is increased, which may lead to serious disturbances in cardiac function. Myocardial hypoxia is associated with impaired energy metabolism in cardiomyocytes, decreased synthesis of adenosine triphosphate (ATP), mitochondrial dysfunction, and disruption of the intracellular environment. These processes contribute to the intensification of oxidative stress, increased production of free radicals, and subsequent damage to cell membranes and organelles. Prolonged hypoxia activates apoptotic and necrotic pathways, resulting in structural and functional alterations of myocardial tissue. This article comprehensively discusses the main pathophysiological mechanisms of myocardial hypoxia at the cellular level, as well as their clinical significance in pediatric patients and their adverse effects on cardiac function.

 

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References

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Published

2026-02-12

How to Cite

Alimjonov Azizulloh. (2026). CELLULAR-LEVEL EFFECTS OF MYOCARDIAL HYPOXIA. Journal of Applied Science and Social Science, 16(02), 545–549. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/3273

Issue

Vol. 16 No. 02 (2026): Volume 16 Issue 02

Section

Articles

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