REGENERATIVE ENDODONTICS: STEM CELL AND BIOMATERIAL APPROACHES
Keywords:
regenerative endodontics, stem cells, biomaterials, tissue engineering, dental pulp regeneration.Abstract
Regenerative endodontics is an emerging field in dentistry that focuses on restoring the structure and function of the dental pulp using stem cells and advanced biomaterials. This approach aims to treat necrotic or damaged pulp tissue while preserving the natural tooth, enhancing both functional and esthetic outcomes. Current strategies involve the use of mesenchymal stem cells, growth factors, scaffolds, and bioactive materials to stimulate tissue regeneration and promote vascularization. Recent studies highlight the potential of regenerative endodontics to revolutionize traditional root canal therapy, reduce tooth loss, and improve patient quality of life. However, challenges remain, including optimizing cell sources, scaffold materials, and clinical protocols for predictable outcomes. Future directions point to personalized regenerative therapies and integration of nanotechnology and tissue engineering techniques in routine endodontic practice [1, 2]
Downloads
References
Murray PE, Garcia-Godoy F, Hargreaves KM. Regenerative endodontics: A review of current status and future directions. J Endod. 2007; 33: 1005–1014.
Becerra P, et al. Dental pulp stem cells and their potential in regenerative endodontics. Stem Cells Int. 2012; 2012: 1–11.
Kim SG, et al. Stem cell-based regenerative endodontics: Clinical perspectives. J Dent Res. 2015; 94: 1433–1440.
Hargreaves KM, Giesler T, Henry M, Wang Y. Regeneration potential of the young permanent tooth: What does the future hold? J Endod. 2008; 34: S51–S56.
Huang GTJ. Dental pulp and dentin tissue engineering and regeneration: Advances and challenges. Front Biosci. 2009; 14: 2760–2771.
Nosrat A, et al. Dental pulp stem cells in regenerative dentistry. J Calif Dent Assoc. 2004; 32: 225–231.
Smith AJ, et al. Scaffold-based strategies for dental pulp regeneration. J Tissue Eng Regen Med. 2016; 10: 113–127.
Tran-Hung L, et al. Bioceramics and synthetic polymers in regenerative endodontics. Dent Mater. 2008; 24: 1113–1121.
Zhang W, et al. Growth factors in pulp regeneration: Current understanding. Stem Cell Res Ther. 2016; 7: 1–9.
Torabinejad M, et al. Challenges and future perspectives in regenerative endodontics. J Endod. 2011; 37: 536–542.
Murray PE, Garcia-Godoy F. Stem cell-based regenerative endodontics: Current status. Int Endod J. 2008; 41: 769–780.
Galler KM, et al. Dentin-pulp complex regeneration: Biological principles and clinical applications. Front Bioeng Biotechnol. 2017; 5: 1–15.
Karamzadeh R, et al. Biomaterials in regenerative endodontics: A review. Mater Sci Eng C Mater Biol Appl. 2017; 71: 1256–1265.
Shabahang S. Regenerative endodontics: Pulp revascularization of immature teeth with necrotic pulps. Endod Topics. 2008; 19: 33–44.
Wigler R, et al. Revascularization: A treatment for permanent teeth with necrotic pulp and incomplete root development. J Endod. 2013; 39: 319–326.
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
All content published in the Journal of Applied Science and Social Science (JASSS) is protected by copyright. Authors retain the copyright to their work, and grant JASSS the right to publish the work under a Creative Commons Attribution License (CC BY). This license allows others to distribute, remix, adapt, and build upon the work, even commercially, as long as they credit the author(s) for the original creation.