VIRAL HEPATITIS A: GENETIC VARIABILITY OF THE VIRUS AND ITS ROLE IN EPIDEMIOLOGY

Authors

  • Makhmudova M.O.,Mirmukhamedov B.B. Master, Department of Environment and Human Health, ASMI,Senior Lecturer, Department of Medical Prevention, ASMI

Keywords:

viral hepatitis A, genetic variability, molecular evolution, epidemiology, diagnostics, immune response, HAV strains.

Abstract

Viral hepatitis A (VHA) is an acute viral liver disease caused by the hepatitis A virus (HAV), which belongs to the Picornaviridae family. Genetic variability of the virus plays an important role in the epidemiology of the disease, determining its spread, diagnosis and features of the immune response. The article discusses the genetic structure of the hepatitis A virus, its molecular features and variations, as well as the impact of genetic variability on clinical manifestations and epidemiological aspects. Data on the molecular evolution of the virus, its strains and subtypes are analyzed, which is important for the development of diagnostic, treatment and prevention methods. The introduction of vaccines and new therapeutic approaches based on molecular data will help to improve the effectiveness of the fight against the disease.

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References

WHO. Hepatitis A. World Health Organization, 2023. Available at: https://www.who.int/news-room/fact-sheets/detail/hepatitis-a

Kuno G., Ching M., & Yip L. (2022). Molecular Evolution of Hepatitis A Virus: Implications for Epidemiology and Vaccine Development. Journal of Viral Hepatitis, 29(6), 515-523.

Cao Y., & Tang X. (2021). Genetic Diversity of Hepatitis A Virus and Its Role in Epidemiology. Frontiers in Microbiology, 12, 639076.

Zhang W., et al. (2020). Hepatitis A Virus Genotype Distribution and Genetic Diversity in Eastern Asia. Emerging Infectious Diseases, 26(4), 852-860.

Mahalingam S., & Williams A. (2021). Hepatitis A Virus: Pathogenesis and Molecular Biology. Infectious Disease Clinics of North America, 35(3), 567-580.

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Published

2024-11-11

How to Cite

Makhmudova M.O.,Mirmukhamedov B.B. (2024). VIRAL HEPATITIS A: GENETIC VARIABILITY OF THE VIRUS AND ITS ROLE IN EPIDEMIOLOGY. Journal of Applied Science and Social Science, 14(11), 49–62. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/347

Issue

Vol. 14 No. 11 (2024): Volume 14 Issue 11

Section

Articles

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