PATHOPHYSIOLOGY OF ADRENOCORTICAL CANCER IN CHILDREN
Keywords:
Adrenocortical cancer, hormone, lymph nodes.Abstract
Adrenocortical cancer in children is a malignant tumor that develops from cells of the adrenal cortex. The main cause of the disease is considered to be the Lee-Fraumeni syndrome and other hereditary pathologies. Manifestations of a hormone-active tumor: Cushing's syndrome, virilization, estrogen-genital syndrome. Hormone-inactive neoplasms occur without clinical symptoms. Ultrasound, MSCT and MRI of the adrenal glands, hormone tests, histological and immunohistochemical studies are used for diagnosis. Treatment includes adrenalectomy to remove the primary tumor, excision of regional lymph nodes, and adjuvant chemotherapy.
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