PATHOPHYSIOLOGY: THE SCIENTIFIC ANALYSIS OF FUNCTIONAL DISORDERS OF THE BODY
Keywords:
pathophysiology, functional disorders, systems biology, biopsychosocial model, neural networks, predictive processing, disease mechanisms, precision medicine, chronic disorders, biomarkers.Abstract
Pathophysiology, as the scientific analysis of functional disorders of the body, plays a crucial role in understanding the mechanisms underlying disease processes. This study explores contemporary perspectives on functional disorders, emphasizing their complex and multifactorial nature. Recent advances in neuroscience, systems biology, and molecular medicine reveal that many disorders arise from dysregulation of interconnected physiological systems rather than structural abnormalities alone. The paper highlights the importance of the biopsychosocial model, predictive processing theories, and network-based approaches in explaining disease mechanisms. Furthermore, challenges related to diagnosis, lack of reliable biomarkers, and gaps in clinical implementation are discussed. The findings underscore the need for integrative, interdisciplinary, and personalized approaches to improve diagnosis, treatment, and healthcare outcomes in modern medicine.
Downloads
References
American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders (5th ed., text rev.; DSM-5-TR). American Psychiatric Publishing.
Borsboom, D. (2017). A network theory of mental disorders. World Psychiatry, 16(1), 5–13. https://doi.org/10.1002/wps.20375
Edwards, M. J., Adams, R. A., Brown, H., Pareés, I., & Friston, K. J. (2019). A Bayesian account of “hysteria.” Brain, 142(7), 2028–2043. https://doi.org/10.1093/brain/awz114
Engel, G. L. (1977). The need for a new medical model: A challenge for biomedicine. Science, 196(4286), 129–136. https://doi.org/10.1126/science.847460
Friston, K. (2018). Does predictive coding have a future? Nature Neuroscience, 21(8), 1019–1021. https://doi.org/10.1038/s41593-018-0200-7
Kirmayer, L. J., & Sartorius, N. (2020). Cultural models and somatic syndromes. Psychosomatic Medicine, 82(1), 1–10. https://doi.org/10.1097/PSY.0000000000000760
McEwen, B. S., & Akil, H. (2020). Revisiting the stress concept: Implications for affective disorders. Journal of Neuroscience, 40(1), 12–21. https://doi.org/10.1523/JNEUROSCI.0733-19.2019
Petersen, A. M., & Pedersen, B. K. (2020). The anti-inflammatory effect of exercise. Journal of Applied Physiology, 98(4), 1154–1162. https://doi.org/10.1152/japplphysiol.00164.2020
Pickkers, P., & van der Poll, T. (2021). Immunopathology of sepsis and potential therapeutic targets. Nature Reviews Immunology, 21(10), 621–636. https://doi.org/10.1038/s41577-021-00512-8
Teixeira, A. L., & Vieira, E. L. M. (2021). Brain–immune interactions in psychiatric disorders. Translational Psychiatry, 11(1), 1–10. https://doi.org/10.1038/s41398-021-01373-0
World Health Organization. (2022). International classification of diseases for mortality and morbidity statistics (11th Revision, ICD-11). https://icd.who.int/
Yuan, H., & Silberstein, S. D. (2021). Neural mechanisms of chronic pain. Current Opinion in Neurology, 34(3), 356–362. https://doi.org/10.1097/WCO.0000000000000934
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
All content published in the Journal of Applied Science and Social Science (JASSS) is protected by copyright. Authors retain the copyright to their work, and grant JASSS the right to publish the work under a Creative Commons Attribution License (CC BY). This license allows others to distribute, remix, adapt, and build upon the work, even commercially, as long as they credit the author(s) for the original creation.