STRUCTURAL CHANGES OF HEPATOCYTES UNDER LONG-TERM STRESS

Authors

  • Atika Ahmedova G’ulomjon qizi, Nuriddinova Nasima Sadriddin qizi,Bobonazarova Xurshida Azamat qizi,Ergashev Sirojiddin Faxriddin o’g’li Assistant of the Department of Anatomy at Tashkent State Medical University,Students of Tashkent State Medical University

Keywords:

Liver; hepatocyte; stress; dystrophic processes; vacuolization; detoxification; apoptosis; necrosis; WHO; pathology; marginalization.

Abstract

Scientific approaches have concluded that long-term stress leads to various physiological and metabolic changes in the body and negatively affects multiple organs. Among these organs, the liver is particularly sensitive to stress factors when metabolic processes are altered. Liver plates are composed of hepatocytes, which play a critical role in metabolism, detoxification, and synthesis processes in the body. This article examines how long-term stress causes vacuolization, predisposition to fatty degeneration, and nuclear morphological changes in hepatocytes. Research results demonstrate that prolonged stress negatively impacts the morphological state of liver cells.

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References

Komiljon Zulfiqorov – Histology, Tashkent State Scientific Publishing House, 2005

McEwen B.S. (2020) – Neurobiology of Stress and the Liver–Brain Axis

Hans Selye – The Stress of Life

Karimov X.; Ahmedov M.A. – Current Problems of Hepatology: Morphological Aspects

Sinelnikov R.D. – Atlas of Human Anatomy

Zukakova N.M. (2022) – Fundamentals of Hepatology and Morphology, Tashkent, “Yangi Asr Avlodi” Publishing

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Published

2026-03-25

How to Cite

Atika Ahmedova G’ulomjon qizi, Nuriddinova Nasima Sadriddin qizi,Bobonazarova Xurshida Azamat qizi,Ergashev Sirojiddin Faxriddin o’g’li. (2026). STRUCTURAL CHANGES OF HEPATOCYTES UNDER LONG-TERM STRESS. Journal of Applied Science and Social Science, 16(03), 844–847. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/3809

Issue

Vol. 16 No. 03 (2026): Journal of Applied Science and Social Science

Section

Articles

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