RABIES VIRUS AND ITS EFFECTS ON THE CENTRAL NERVOUS SYSTEM

Authors

  • Kasimova Iroda Kadirovna Andijan state medical institute

Keywords:

Rabies virus, neurotropic virus, central nervous system, encephalitis, pathogenesis

Abstract

Rabies virus is a highly neurotropic pathogen that causes a fatal encephalitic disease affecting the central nervous system (CNS) of humans and animals. Despite the availability of effective vaccines, rabies remains a significant public health concern in many parts of the world, particularly in developing countries. The virus exhibits a unique pathogenic mechanism, entering peripheral nerves and traveling retrogradely to the CNS, where it causes progressive neurological dysfunction. This article aims to analyze the effects of rabies virus on the central nervous system, focusing on its pathogenesis, mechanisms of neural invasion, clinical manifestations, diagnostic approaches, and treatment challenges. The findings emphasize the importance of early intervention and preventive strategies to reduce mortality.

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References

Jackson, A. C. (2013). Rabies: Scientific basis of the disease.

Hemachudha, T., et al. (2013). Rabies pathogenesis. Lancet Neurology, 12(5), 498–513.

World Health Organization. (2021). Rabies epidemiology report.

Fooks, A. R., et al. (2017). Rabies virus biology. Nature Reviews Microbiology, 15(6), 347–358.

Schnell, M. J., et al. (2010). Rabies virus entry mechanisms.

Lafon, M. (2005). Rabies virus and neurons.

Banyard, A. C., et al. (2013). Clinical rabies manifestations.

Scott, T. P., et al. (2008). Immune evasion in rabies.

Rupprecht, C. E., et al. (2010). Rabies diagnosis and management.

WHO. (2018). Rabies vaccines and prophylaxis.

Jackson, A. C. (2016). Current rabies research.

Warrell, M. J. (2015). Rabies treatment advances.

Dietzschold, B., et al. (2008). Pathogenesis of rabies.

Kuzmin, I. V., et al. (2011). Lyssavirus diversity.

Hampson, K., et al. (2015). Rabies burden worldwide.

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Published

2026-03-27

How to Cite

Kasimova Iroda Kadirovna. (2026). RABIES VIRUS AND ITS EFFECTS ON THE CENTRAL NERVOUS SYSTEM. Journal of Applied Science and Social Science, 16(03), 915–918. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/3826

Issue

Vol. 16 No. 03 (2026): Journal of Applied Science and Social Science

Section

Articles

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