ROLE OF LYSYL OXIDASE IN THE PATHOGENESIS OF INTERSTITIAL LUNG INJURY

Authors

  • Rikhsi Sabirova, Djakhangir Tursunov DSc, Professor Tashkent State Medical University, PhD, Associate Professor Tashkent State Medical University

Keywords:

lysyl oxidase; LOX-1–4; interstitial pneumonia; lung fibrosis; biomarkers; tissue remodeling; extracellular matrix; experimental model.

Abstract

This study investigates the activity of lysyl oxidase family enzymes (LOX-1–4) in experimental interstitial pneumonia. All LOX isoforms demonstrated a marked increase—more than 2.7-fold—in serum and lung homogenates compared with intact animals, indicating enhanced fibrotic and tissue-remodeling processes. LOX-3 showed the highest baseline activity. These findings confirm the pivotal role of LOX enzymes in the pathogenesis of interstitial lung injury and support the potential use of LOX-1–4 as biomarkers for assessing fibrosis severity and progression.

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References

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Published

2026-03-29

How to Cite

Rikhsi Sabirova, Djakhangir Tursunov. (2026). ROLE OF LYSYL OXIDASE IN THE PATHOGENESIS OF INTERSTITIAL LUNG INJURY. Journal of Applied Science and Social Science, 16(03), 1076–1079. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/3862

Issue

Vol. 16 No. 03 (2026): Journal of Applied Science and Social Science

Section

Articles

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