ORIGINS AND TREATMENTS OF AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME
Keywords:
Autoimmune lymphoproliferative syndrome , lymphadenopathy, splenomegaly.Abstract
Autoimmune lymphoproliferative syndrome is a group of genetically determined diseases that occur due to hereditary or somatic mutations in the genes responsible for various stages of FAS-related apoptosis. Symptoms can be variable and most often include lymphadenopathy, splenomegaly, and various autoimmune lesions of the blood, liver, and thyroid systems. Diagnosis of autoimmune lymphoproliferative syndrome is based on the results of general and biochemical blood tests, lymph node biopsies, and genetic studies. There is currently no specific treatment for the disease, but a combination of immunosuppressive and cytotoxic therapy is used.
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