MOLECULAR-GENETIC MECHANISMS OF MALIGNANT TUMOR DEVELOPMENT: THE PROCESS OF TRANSFORMATION OF PROTO-ONCOGENES INTO ONCOGENES.

Authors

  • Abdukakhhorova Chamanoy Lecturer of the Department of Histology and Biology Fergana Institute of Public Health Medicine
  • Foziljonova Marjona Anvarjon qizi 1st stage student Faculty of Pediatrics Pediatrics Department

Keywords:

Malignant tumors, proto-oncogene, oncogene, molecular-genetics, mutation, gene amplification, chromosome translocation, cell proliferation, apoptosis, signal transduction. Malignant neoplasms are one of the most pressing problems of modern medicine and are one of the main causes of human death. The

Abstract

 The development of malignant tumors is a complex    molecular-genetic process, which is based on the disruption of genes that control cell proliferation and differentiation. This article analyzes the mechanisms of the transformation of proto-oncogenes into oncogenes, including point mutations, gene amplification, chromosomal translocations, and the effects of viruses. Also, the activation of cell signaling pathways and their interaction with tumor suppressor genes are studied. These changes at the molecular level determine the main stages of tumor development and are of great importance in the development of modern oncological diagnostics and targeted therapies.

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Published

2026-05-12

How to Cite

Abdukakhhorova Chamanoy, & Foziljonova Marjona Anvarjon qizi. (2026). MOLECULAR-GENETIC MECHANISMS OF MALIGNANT TUMOR DEVELOPMENT: THE PROCESS OF TRANSFORMATION OF PROTO-ONCOGENES INTO ONCOGENES. Journal of Applied Science and Social Science, 16(5), 419–421. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/4347

Issue

Vol. 16 No. 5 (2026): Journal of Applied Science and Social Science

Section

Articles

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