NEUROHUMORAL MECHANISMS IN PATIENTS WITH HEART FAILURE ON THE BACKGROUND OF METABOLICALLY ASSOCIATED FATTY LIVER DISEASE
Keywords:
Heart failure, MAFLD, neurohumoral, RAAS, SNS, inflammation, oxidative stress, cytokines, cardiometabolic, metabolism.Abstract
This article explores neurohumoral mechanisms in patients with heart failure (HF) occurring in the context of metabolically associated fatty liver disease (MAFLD). The interaction between cardiac dysfunction and metabolic liver alterations is analyzed through the activation of neurohormonal systems, including the renin–angiotensin–aldosterone system (RAAS), sympathetic nervous system (SNS), and inflammatory cytokine pathways. The study highlights how metabolic dysfunction in the liver intensifies systemic inflammation, oxidative stress, and neurohormonal imbalance, thereby worsening heart failure progression. The findings emphasize the importance of integrated cardiometabolic approaches in diagnosis and treatment strategies for such patients.
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