INTRATUMORAL MICROBIOME: A NEW PARADIGM IN CANCER DIAGNOSIS AND THERAPY
Keywords:
Intratumoral microbiome, metagenomic sequencing (mNGS), tumor microenvironment (TME), oncogenesis, microbial biomarkers, chemoresistance, bacteriophage therapy, liquid biopsy, cmDNA, personalized oncology.Abstract
For a long time, tumor tissues were traditionally considered sterile environments; however, recent metagenomic advancements between 2020 and 2026 have fundamentally shifted this perspective, revealing that every tumor type possesses a distinct "microbial signature." This article analyzes the role of the intratumoral microbiome in oncogenesis, metastasis, and drug resistance as a new paradigm in oncology. The study highlights the spatial distribution of microorganisms within the tumor microenvironment, their ability to modulate immune responses, and the mechanisms behind microbial-induced chemoresistance. A significant emphasis is placed on the diagnostic potential of metagenomic Next-Generation Sequencing (mNGS) for early cancer detection. Furthermore, based on oncological statistics from Uzbekistan, the paper proposes strategic frameworks for integrating microbial monitoring into clinical practice and developing personalized therapeutic approaches, such as phage therapy and microbial modulation, to enhance treatment efficacy.
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