MODERN DIAGNOSIS AND TREATMENT HEAVY CHAIN DISEASES
Keywords:
paraproteinemic hemoblastosis, cytostatics, enlarged liver, spleen, lymph nodes, diarrhea, edema, exhaustion.Abstract
Heavy chain diseases (BTCs) are rare tumor diseases of a lymphoproliferative nature, in which defective immunoglobulins are synthesized (with missing light chain fragments). There are several variants of the disease-BTC-α, BTC-γ, BTC-µ and BTC-δ. Clinical manifestations are caused by damage to the lymphatic system and hematopoietic organs (enlarged liver, spleen, lymph nodes, diarrhea, edema, exhaustion, etc.). Diagnosis is based on complex immunopathochemical studies. Treatment is aimed at suppressing the tumor process using polychemotherapy (cytostatics, corticosteroids according to the scheme).
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