MICROBIAL LANDSCAPE OF THE ENDOMETRIUM IN PATIENTS WITH CHRONIC ENDOMETRITIS.

Authors

  • Ikramova N.A.Chartaeva A.E. RIOvaBSIATM

Keywords:

chronic endometritis; women of reproductive age; endometrium; microbiota; microorganisms.

Abstract

The aim of the study was to investigate the microbiological features of chronic endometritis (CE) in women of reproductive age. A total of 76 patients with histologically confirmed CE were examined, divided into two groups according to the degree of inflammation activity. Real-time PCR with the Femoflor-16 kit was used to analyze the endometrial microbiota. In patients without CE, the microbiota was predominantly represented by Lactobacillus spp. (85.0%) and Eubacterium spp. (60.0%). In moderate CE, Streptococcus spp., Staphylococcus spp. and Enterobacteriaceae spp. were detected more often, while associations of Mobiluncus spp./Corynebacterium spp. and Gardnerella vaginalis/Prevotella bivia/Porphyromonas spp. were less common (p < 0.05).

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References

Casari E., Ferrario A., Morenghi E., et al. Gardnerella, Trichomonas vaginalis, Candida, Chlamydia trachomatis, Mycoplasma hominis and Ureaplasmaure alyticum in the genital discharge of symptomatic fertile and asymptomatic infertile women // New Microbiol. 2010. Vol. 33. №1. P.69-76.

Chen C., Song X., Wei W., et al. The microbiota continuum along the female reproductive tract and its relation to uterinerelated diseases // Nat Commun. 2017. Vol. 8. №1. P.875. DOI: 10.1038/s41467-017-00901-0.

Johnston-MacAnanny E.B., Hartnett J., Engmann L.L., Nulsen J.C., Sanders M.M., Benadiva C.A. Chronic endometritis is a frequent finding in women with recurrent implantation failure after in vitro fertilization. Fertil Steril 2010; 93: 2: 437—441.

McQueen D.B., Bernardi L.A., Stephenson M.D. Chronic endometritis in women with recurrent early pregnancy loss and/or fetal demise. Fertil Steril. 2014 Apr; 101: 4: 1026—1030.

Carvalho F.M., Aguiar F.N., Tomioka R., Oliveira R.M., Frantz N., Ueno J. Functional endometrial polyps in infertile asymptomatic patients: a possible evolution of vascular changes secondary to endometritis. Eur J Obst Gynecol Reprod Biol 2013; 170: 152—156.

Ju J., Li L., Xie J., Wu Y., Wu X., Li W. Toll-like receptor-4 pathway is required for the pathogenesis of human chronic endometritis. Exp Ther Med 2014 Dec; 8: 6: 1896—1900.

Matteo M., Cicinelli E., Greco P., Massenzio F., Baldini D., Falagario T. et al. Abnormal pattern of lymphocyte subpopulations in the endometrium of infertile women with chronic endometritis. Am J Reprod Immunol 2009; 61: 5: 322—329.

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Published

2025-03-27

How to Cite

Ikramova N.A.Chartaeva A.E. (2025). MICROBIAL LANDSCAPE OF THE ENDOMETRIUM IN PATIENTS WITH CHRONIC ENDOMETRITIS. Journal of Applied Science and Social Science, 15(03), 763–766. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/855

Issue

Vol. 15 No. 03 (2025): Volume 15 Issue 03

Section

Articles

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