MORPHOLOGICAL CHANGES IN THE HEART UNDER EXPERIMENTAL HYPOKINESIA

Authors

  • S.M. Akhmedova, J.S. Turobov, Q.S. Komilov x

Keywords:

Hypokinesia, Morphological changes in the heart, Interstitial fibrosis, Myocardial dilatation, Cardiac hypertrophy, Pathophysiological mechanisms, Metabolic dysfunction, Oxidative stress, Mitochondrial dysfunction, Inflammatory processes, Apoptosis, Heart failure, Arrhythmias, Microscopic changes, Impact of physical activity on the heart, Regular physical activity, Cardiovascular diseases, Clinical outcomes, Experimental research, Preventive measures.

Abstract

This article analyzes the morphological changes in the heart caused by physical inactivity (hypokinesia), their pathophysiological mechanisms, and clinical significance based on international sources. Studies show that hypokinesia promotes myocardial dilatation, hypertrophy, and interstitial fibrosis processes. Consequently, the heart's pumping function declines, increasing the risk of heart failure, arrhythmias, and other cardiovascular diseases. These processes are visually represented through graphical data.

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References

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Haskell WL, Lee IM, Pate RR, et al. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation. 2007;116(9):1081–1093.

Lavie CJ, De Schutter A, Patel DA, et al. Exercise and cardiovascular health: a review of recent clinical evidence. Circulation. 2015;132(8):813–822.

Swift DL, McGee JE, Earnest CP, et al. The role of exercise and physical activity in weight loss and maintenance. Mayo Clin Proc. 2013;88(8):963–975.

Lee IM, et al. Physical activity and coronary heart disease in men. N Engl J Med. 1995;332(12):912–918.

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Published

2025-04-01

How to Cite

S.M. Akhmedova, J.S. Turobov, Q.S. Komilov. (2025). MORPHOLOGICAL CHANGES IN THE HEART UNDER EXPERIMENTAL HYPOKINESIA. Journal of Applied Science and Social Science, 15(03), 947–950. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/892

Issue

Vol. 15 No. 03 (2025): Volume 15 Issue 03

Section

Articles

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