LABORATORY DIAGNOSIS IN SEPSIS AND ITS PATHOPHYSIOLOGICAL BASIS
Keywords:
Sepsis, Pathophysiology, Laboratory diagnostics, Systemic inflammatory response, Coagulation system, Microangiopathy, Procalcitonin, C-reactive protein, Lactate, D-dimer.Abstract
This work provides a detailed analysis of laboratory diagnostics of sepsis and its pathophysiological basis. The systemic inflammatory reactions and coagulation system disorders that occur in the body during the development of sepsis are scientifically reviewed. The role of laboratory diagnostic methods, including a complete blood count, C-reactive protein (CRP), procalcitonin (PCT), lactate level, D-dimer and microbiological tests in the diagnosis is revealed. The importance of each laboratory parameter in the detection and assessment of the severity of sepsis is also highlighted. The need for changes in laboratory parameters based on pathophysiological mechanisms and the need to make clinical decisions based on them is scientifically substantiated. The study emphasizes the vital importance of early diagnosis of sepsis, proper monitoring and treatment strategies. The results of the work show that a correct understanding of the laboratory examination and pathophysiology of sepsis can improve the quality of life of patients and reduce mortality.
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