ANTIRADICAL ACTIVITY OF BIOACTIVE SUBSTANCES
Keywords:
dihydroquercetin (DHQ), isoquinoline alkaloids, DKV-11 conjugate, antiradical activity, antioxidant properties, DPPH assay, oxidative stress, free radical scavenging, pharmacological potential.Abstract
This study investigates the antioxidant and antiradical activities of bioactive compounds—dihydroquercetin (DHQ), isoquinoline alkaloids, and their synthetic conjugate DKV-11. Oxidative stress, caused by free radicals, contributes to various diseases, including cardiovascular disorders, cancer, and neurodegenerative conditions. Natural antioxidants, such as flavonoids and alkaloids, play a crucial role in neutralizing free radicals and protecting cells from oxidative damage. The research evaluates the radical scavenging activity of DHQ, isoquinoline alkaloids, and DKV-11 using the DPPH (1,1-diphenyl-2-picrylhydrazyl) assay. Results demonstrate that DKV-11 exhibits the highest antiradical activity (IC50 = 3.5 µM), significantly surpassing DHQ (IC50 = 45.3 µM). The findings highlight the potential of DKV-11 as a potent antioxidant agent for pharmacological applications, supporting further research into its therapeutic benefits.
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