CLINICAL AND INSTRUMENTAL CHARACTERISTICS OF THE COURSE AND PROGNOSIS IN CHILDREN WITH TETRALOGY OF FALLOT

Authors

  • Xasanova F.D. Master’s Student, Andijan State Medical Institute
  • Zokirov B.Q. Scientific Supervisor, PhD, docent, Department of Hospital Pediatrics, Andijan State Medical Institute
  • Yefimenko.O.V. Scientific Consultant, PhD, docent, Department of Hospital Pediatrics, Andijan State Medical Institute

Keywords:

Tetralogy of Fallot, congenital heart defects, echocardiography, hypoxic spells, prognosis, pediatrics.

Abstract

English: Background: Tetralogy of Fallot (ToF) is the most common cyanotic congenital heart defect (CHD). The clinical course and prognosis depend heavily on the degree of right ventricular outflow tract obstruction (RVOTO). Objective: To study the clinical and instrumental features of Tetralogy of Fallot in children in the Andijan region and to determine prognostic factors affecting the disease course. Methods: A retrospective analysis of 60 children aged 6 months to 5 years diagnosed with ToF was conducted. Patients were assessed using pulse oximetry, ECG, and Doppler Echocardiography. The McGoon ratio was used to assess pulmonary artery anatomy. Results: The study identified that 75% of patients presented with "classic" cyanotic forms, while 25% had "pale" forms. A strong inverse correlation was found between the McGoon ratio and the frequency of hypoxic spells (r = -0.72). Children with a McGoon ratio <1.2 had a significantly worse prognosis and higher pre-operative morbidity. Conclusion: The clinical severity of ToF is directly related to the morphometric parameters of the pulmonary arteries. Early instrumental assessment allows for risk stratification and timely surgical intervention, improving the long-term prognosis.

Downloads

Download data is not yet available.

References

Bokeria, L. A., & Alekyan, B. G. (2020). Endovascular diagnostics and treatment of heart diseases. SCVESS.

Starr, J. P. (2019). Tetralogy of Fallot: Yesterday and today. World Journal of Surgery, 34(4), 658-668.

Van der Ven, J. P. G., van den Bosch, E., Bogers, A. J. C. C., & Helbing, W. A. (2021). Current outcomes and treatment of tetralogy of Fallot. F1000Research, 8, F1000 Faculty Rev-1530. https://doi.org/10.12688/f1000research.17174.1

Apitz, C., Webb, G. D., & Redington, A. N. (2018). Tetralogy of Fallot. The Lancet, 374(9699), 1462-1471.

World Health Organization. (2022). Congenital anomalies: Fact sheet. Retrieved from who.int.

Zokirov, N. U., & Abdullaeva, M. E. (2021). Features of hemodynamic correction in children with congenital heart defects in the Fergana Valley. Central Asian Journal of Medicine, 2(1), 45-50.

Downloads

Published

2025-12-11

How to Cite

Xasanova F.D., Zokirov B.Q., & Yefimenko.O.V. (2025). CLINICAL AND INSTRUMENTAL CHARACTERISTICS OF THE COURSE AND PROGNOSIS IN CHILDREN WITH TETRALOGY OF FALLOT. Journal of Applied Science and Social Science, 15(12), 331–335. Retrieved from https://www.internationaljournal.co.in/index.php/jasass/article/view/2588

Issue

Vol. 15 No. 12 (2025): Volume 15 Issue 12

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All content published in the Journal of Applied Science and Social Science (JASSS) is protected by copyright. Authors retain the copyright to their work, and grant JASSS the right to publish the work under a Creative Commons Attribution License (CC BY). This license allows others to distribute, remix, adapt, and build upon the work, even commercially, as long as they credit the author(s) for the original creation.